OPUS 12 Foundation                              
Mark J. Seamon, MD

Mark J. Seamon, MD


Curriculum Vitae


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Education and training:
  • 1991 to 1995 - Bachelor of Arts in Biology, Wesleyan University, Middeltown, CT, USA.
  • 1997 to 2001 - Doctor of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • 2001 to 2006 - General Surgery Residency, Temple University Hospital, Philadelphia, PA, USA.
  • 2007 to Present - OPUS 12 Foundation, Blue Bell, PA, USA
    • Jan 2007 to Sep 2007 - VP for Academic Affairs and Director of Critical Care Research.
    • Sep 2007 - Present - Vice Chairman, VP for Academic Affairs and Director of Critical Care Research.

Awards and honors:

  • Recipient of Robert Jones Award for outstanding service to the community

Peer-reviewed journal publications:

  1. FOLLICULAR LYMPHOMAS CAN BE INDUCE TO PRESENT ALLOANTIGEN EFFICIENTLY: A CONCEPTUAL MODEL TO IMPROVE THEIR TUMOR IMMUNOGENICITY. JL Schultze, AA Cardoso, GJ Freeman, MJ Seamon, J Daley, GS Pinkus, JG Gribben, LM Nadler. Proc Natl Acad Sci USA. 1995;92(18):8200-8204.
  2. PRE-B ACUTE LYMPHOBLASTIC LEUKEMIA CELLS MAY INDUCE T-CELL ANERGY TO ALLOANTIGEN. AA Cardoso, JL Schultze, VA Boussiotis, GJ Freeman, MJ Seamon, S Laszlo, SE Sallan, JG Gribben, LM Nadler. Blood. 1996;88(1):41-48.
  3. AUTOLOGOUS TUMOR  INFILTRATING T CELLS CYTOTOXIC FOR FOLLICULAR LYMPHOMA CELLS CAN BE EXPANDED IN VITRO. JL Schultze, MJ Seamon, S Michalak, JG Gribben, LM Nadler. Blood. 1997;89(10):3806-1816.
  4. EX VIVO GENERATION OF HUMAN ANTI-PRE-B LEUKEMIA-SPECIFIC AUTOLOGOUS CYTOLYTIC T CELLS. AA Cardoso, MJ Seamon, HM Afonso, P Ghia, VA Boussiotis, GJ Freeman, SE Sallan, LM Nadler. Blood. 1997;90(2):549-561.
  5. CD-40-ACTIVATED HUMAN B CELLS: AN ALTERNATIVE SOURCE OF HIGHLY EFFICIENT ANTIGEN PRESENTING CELLS TO GENERATE AUTOLOGOUS ANTIGEN-SPECIFIC T CELLS FOR ADOPTIVE IMMUNOTHERAPY. JL Schultze, S Michalak, MJ Seamon, G Dranoff, K Jung, J Daley, JC Delgado, JG Gribben, LM Nadler. J Clin Invest. 1997;100(11):2757-2765.
  6. A TEN YEAR RETROSPECTIVE REVIEW: DOES PYLORIC EXCLUSION OFFER BENEFIT TO PENETATING DUODENAL AND COMBINED PANCREATIC-DUODENAL INJURIES? MJ Seamon MD, P Pieri MD, et al. Journal of Trauma. 2007;62:829-833.
  7. THYROCERVICAL TRUNK TRANSECTION: A RARE CAUSE OF MASSIVE HEMOTHORAX. MJ Seamon MD, Choudry R, Santora T, Goldberg A, Roberts A, Pathak A, Bradley K. Journal of Trauma. 2007 Jun;62(6):1534.
  8. THE INCIDENTAL MECKEL'S DIVERTICULUM IN TRAUMA: A CASE REPORT AND LITERATURE REVIEW. MJ Seamon MD, et al. Journal of Trauma. 2007. Accepted for publication.
  9. PRE-HOSPITAL PROCEDURES BEFORE EMERGENCY DEPARTMENT THORACOTOMY: "SCOOP AND RUN" SAVES LIVES. MJ Seamon MD, et al. Journal of Trauma. 2007 Jul;63(1):113-120.
  10. TRANSTHORACIC ECHOCARDIOGRAPHY FOR PULMONARY EMBOLISM IN THE ICU: FINDING THE 'RIGHT' FINDINGS. SP Stawicki MD, MJ Seamon MD, DM Meredith CRNP, J Chovanes DO, PK Kim MD, CW Schwab MD, VH Gracias MD. Journal of the American College of Surgeons. 2007;():.
  11. PREHOSPITAL PROCEDURES BEFORE EMERGENCY DEPARTMENT THORACOTOMY: "SCOOP AND RUN" SAVES LIVES. MJ Seamon MD, CA Fisher MD, J Gaughan MD, et al. J Trauma. 2007 Jul;63(1):113-120.
  12. COMPLICATIONS RELATED TO PERCUTANEOUS ENDOSCOPIC GASTROSTOMY (PEG) TUBES: A COMPREHENSIVE CLINICAL REVIEW. SP Schrag MD, R Sharma MD, NP Jaik MD, MJ Seamon MD, JJ Lukaszczyk MD, ND Martin MD, BA Hoey MD, SP Stawicki MD. Journal of Gastrointestinal and Liver Diseases. 2007 Dec;():.

Book chapters:

  1. ICU CARE OF THE TRAUMA PATIENT. MJ Seamon MD, JP Pryor MD, CW Schwab MD. In: Trauma Care - Decision Making and Surgical Techniques, First Edition, McGraw Hill, in press.
  2. INJURIES OF THE DUODENUM. MJ Seamon MD, AS Pathak, AJ Goldberg MD. In: Shackleford's Surgery of the Alimentary Tract, Sixth Edition, Philadelphia, Pennsylvania, W. B. Saunders, 2007.
  3. PENETRATING ABDOMINAL TRAUMA. MJ Seamon MD. In: Mann's Surgery: A Competency-Based Companion, First Edition, in press.
  4. MULTIPLE SYSTEM ORGAN FAILURE. MJ Seamon MD. In: Mann's Surgery: A Competency-Based Companion, First Edition, in press.

Published abstracts:
  1. MOST FOLLICULAR LYMPHOMAS DO NOT STIMULATE AN ALLOGENIC T-CELL PROLIFERATIVE RESPONSE. JL Schultze, MJ Seamon, S Michalak, GJ Freeman, JG Gribben, LM Nadler. Blood. 1994;84(10):A521.
  2. EXPRESSION AND INDUCTION OF B7 COSTIMULATORY MOLECULES ON B-CELL PRECURSOR MALIGNANCIES: IMPLICATIONS FOR ANTI-TUMOR IMMUNITY. AA Cardoso, JL Schultze, MJ Seamon, A Provan, GJ Freeman, JG Gribben, LM Nadler. Blood. 1994;84(10):A378.
  3. BYSTANDER ANTIGEN PRESENTING CELLS REPAIR DEFECTIVE ANTIGEN PRESENTATION BY PRE-B ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL) CELLS. AA Cardoso, JL Schultze, MJ Seamon, VA Boussiotis, GJ Freeman, JG Gribben, LM Nadler. Blood. 1995;86(10):173.
  4. ABSENCE OF ANTI-FOLLICULAR LYMPHOMA SPECIFIC T CELL MEDIATED IMMUNITY IS ASSOCIATED WITH SIGNIFICANT REDUCTION OF T CELL RECEPTOR GAMMA CHAIN AND GRANZYME B EXPRESSION. JL Schultze, VA Boussiotis, D Dorfman, AA Cardoso, MJ Seamon, HM Afonso, JG Gribben, LM Nadler. Blood. 1995;86(10):1074.
  5. INDUCTION AND AMPLIFICATION OF ANTI-FOLLICULAR LYMPHOMA SPECIFIC CYTOLYTIC T CELLS IN VITRO: POTENTIAL FOR ADOPTIVE TRANSFER. JL Schultze, AA Cardoso, MJ Seamon, JG Gribben, LM Nadler. Blood. 1995;86(10):2398.
  6. B7-1, B7-2 PRE B ALL DO NOT GENERATE ALLOANTIGEN SPECIFIC IMMUNITY BUT RATHER INDUCE T CELL ANERGY. AA Cardoso, JL Schultze, MJ Seamon, VA Boussitis, GJ Freeman, JG Gribben, LM Nadler. Blood. 1995;86(10):1732.
  7. ON HUMAN B CELL MALIGNANCIES BB1 APPEARS TO BE A MOLECULE DISTINCT FROM B7-1 WHICH PROVIDES A NEGATIVE SIGNAL TO T CELLS. AA Cardoso, JL Schultze, MJ Seamon, GJ Freeman, JG Gribben, HM Afonso, VA Boussiotis, LM Nadler. Blood. 1995;86(10):1268.
  8. ADVANTAGES OF HUMAN CD40 ACTIVATED B-CELLS OVER DENDRITIC CELLS FOR PRESENTATION OF HUMAN TUMOR ANTIGENS. JL Schultze, MJ Seamon, S Michalak, JC Delgado, JG Gribben, LM Nadler. Blood. 1996;88(10):636.
  9. POTENTIAL FOR ADOPTIVE THERAPY FOR PRE-B CELL LEUKEMIA: EX-VIVO GENERATION OF ANTI-LEUKEMIA SPECIFIC AUTOLOGOUS CD8+ CYTOLYTIC T-CELLS. AA Cardoso, MJ Seamon, HM Alfonso, SE Sallan, VA Boussiotis, GJ Freeman, JG Gribben, LM Nadler. Blood. 1996;88(10):835.
  10. PRE-B ALL CELLS PRODUCE FUNCTIONAL TGF-B1 THAT INHIBITS BOTH EARLY HEMATOPOIESIS AND T-CELL ACTIVATION THERAPY FACILITATING LEUKEMIA CELL GROWTH. AA Cardoso, MJ Seamon, HM Afonso, D McCullough, SE Sallan, JG Gribben, LM Nadler. Blood. 1996;88(10):2652.
  11. CD40 ACTIVATED FOLLICULAR LYMPHOMA CELLS ARE RESISTANT TO AND CAN OVERCOME GENERALIZED T-CELL UNRESPONSIVENESS INDUCED BY IL-10 AND TGF-B. JL Schultze, MJ Seamon, S Michalak, JG Gribben, LM Nadler. Blood. 1996;88(10):2534.

Local presentations:

  1. EMERGENCY DEPARTMENT THORACOTOMY: THE TEMPLE EXPERIENCE. MJ Seamon MD. Department of Surgery Grand Rounds, Temple University Hospital (Jun 2006) Philadelphia, Pennsylvania.
  2. LESSONS LEARNED FROM PANCREATIC INJURIES IN DAMAGE CONTROL LAPAROTOMIES. MJ Seamon MD, PK Kim MD, CW Schwab MD. Oral presentation at the 2006 Pennsylvania Committee on Trauma Meeting (Oct 2006) Harrisburg, Pennsylvania.
  3. TRANSTHORACIC ECHOCARDIOGRAPHY FOR TRIAGING PULMONARY EMBOLISM: FINDING THE 'RIGHT' FINDINGS. SP Stawicki MD, MJ Seamon MD, DM Meredith CRNP, J Chovanes DO, PK Kim MD, VH Gracias MD. Oral presentation at the 2006 Pennsylvania Committe on Trauma Meeting (Oct 2006) Harrisburg, Pennsylvania.
  4. COMPETING PRIORITIES IN A BLUNT MULTI-INJURED PATIENT. MJ Seamon MD. Oral presentation at the Annual Day of Trauma Meeting (Dec 2006) Philadelphia, Pennsylvania.

Regional presentations:
  1. A TEN YEAR RETROSPECTIVE REVIEW: DOES PYLORIC EXCLUSION OFFER BENEFIT TO PENETRATING DUODENAL AND COMBINED PANCREATIC-DUODENAL INJURIES. MJ Seamon MD, P Pieri MD, et al. Poster presentation at the 19th Annual EAST Meeting (Jan 2006) Orlando, Florida.

National presentations:
  1. FOLLICULAR LYMPHOMA CELLS STIMULATED THROUGH CD40 CAN PRIME ALLOANTIGEN-SPECIFIC T CELL RESPONSES AGAINST PRIMARY MALIGNANT CELLS. JL Schultze, AA Cardoso, MJ Seamon, GJ Freeman, JG Gribben, LM Nadler. Poster presentation at the 1996 American Society of Hematology Meeting.
  2. ANTIGEN-PRESENTING FUNCTION OF B-CELL PRECURSOR MALIGNANT CELLS CAN BE MODULATED BY CROSSLINKING OF CD40. AA Cardoso, JL Schultze, A Provan, GJ Freeman, MJ Seamon, JG Gribben, LM Nadler. Poster presentation at the 1996 American Society of Hematology Meeting.
  3. ANTI-CD40 MAB AND MACROPHAGE SUPERNATANT STIMULATE CD25 EXPRESSION ON HUMAN MONOCYTE DERIVED DC'S. MJ Seamon MD, RB Malliard, MT Lotze. Poster presentation at the 1998 Biological Therapy of Cancer XIII Meeting.
  4. PREPARING SURGICAL RESIDENTS FOR PAY FOR PERFORMANCE: A MODEL FOR PROCEDURE OUTCOMES REPORTING. DA Berg MD, MJ Seamon MD, CA Fisher BA, RE Milner BS, H Grewal MD, S Kim MD, DT Dempsey MD, AJ Goldberg MD. Oral presentation at the 2006 APDS Meeting (Mar 2006).
  5. COMMUNICATION SKILLS TRAINING OF SURGICAL RESIDENTS ENHANCES PERFORMANCE IN END OF LIFE SIMULATIONS. AJ Goldberg MD, R Milner BS, CA Fisher BA, J Gaughan PhD, J Travaline MD, M Jacobson MD, MJ Seamon MD, K Soo MD. Oral presentation at the 2007 APDS Meeting.
  6. STAY AND PLAY INTERVENTION ON UNSTABLE PENETRATING TRAUMA PATIENTS: IS THERE AN ASSOCIATION WITH INCREASED SURVIVAL? MJ Seamon MD, D Gupta MD, C Fisher BA, D Nayduch RN, KM Bradley MD, TA Santora MD, AS Pathak MD, AJ Goldberg MD. Poster presentation at the 2006 AAST Meeting (Sep 28-30, 2006) New Orleans, Louisiana.
  7. EMERGENCY DEPARTMENT THORACOTOMY: SURVIVAL IS THE LEAST EXPECTED. MJ Seamon MD, DT Dempsey MD, AJ Goldberg MD. Oral presentation at the ISW/IATSIC 2007 Meeting (Aug 2007).
  8. EMERGENCY DEPARTMENT THORACOTOMY: STILL USEFUL AFTER ABDOMINAL EXSANGUINATION? MJ Seamon MD, AS Pathak MD, KM Bradley MD, CA Fisher BA, J Gaughan PhD, H Kulp RN MPH, PG Pieri MD, TA Santora MD, AJ Goldberg MD. Oral presentation at the 2007 AAST Meeting (Sep 2007).